[{"experiment_id":"ARCHIE-000","title":"Cross-Species Validation","status":"VALIDATED","research_question":"Can Archie independently rediscover established cross-species cancer biology?","iteration_id":"ARCHIE-000A","iteration_title":"Cross-species gene intersection","iteration_status":"FAILED","result_summary":"Ten significant enrichment terms were identified, including sustaining proliferative signalling, but NF-kB or an equivalent NF-kB activation signature did not emerge. The method therefore failed the predefined validation criterion."},{"experiment_id":"ARCHIE-000","title":"Cross-Species Validation","status":"VALIDATED","research_question":"Can Archie independently rediscover established cross-species cancer biology?","iteration_id":"ARCHIE-000B","iteration_title":"Independent pathway convergence","iteration_status":"FAILED","result_summary":"Independent species-level enrichment identified substantial shared lymphoma biology, including immune-system regulation, leukocyte and lymphocyte activation, T-cell activation, cell-surface receptor signalling and proliferation. However, NF-kB signalling or an equivalent NF-kB activation process did not independently emerge as significant in both species or as a significant shared pathway. ARCHIE-000B therefore failed its preregistered primary validation criterion."},{"experiment_id":"ARCHIE-000","title":"Cross-Species Validation","status":"VALIDATED","research_question":"Can Archie independently rediscover established cross-species cancer biology?","iteration_id":"ARCHIE-000C","iteration_title":"Published pathway replication","iteration_status":"PASSED","result_summary":"Blind reanalysis of canine DLBCL recovered 32 of 105 published GO benchmark terms by conservative exact-name matching: 8/41 upregulated and 24/64 downregulated. Overall recovery was 30.5%, 38.58 times the random overlap expectation. In 100,000 seeded random simulations, the maximum combined overlap was 8 versus 32 observed. Exact hypergeometric p-values were 1.23e-09 for upregulated and 1.57e-35 for downregulated. GO hierarchy and term dependence mean these probabilities should not be interpreted as independent-term probabilities. The result demonstrates substantial directionally coherent replication of previously published canine DLBCL biology."},{"experiment_id":"ARCHIE-001","title":"Cross-Species Lymphoma Discovery","status":"ACTIVE","research_question":"Which molecular vulnerabilities are conserved across canine, feline and human T-cell lymphoma, and which therapeutic opportunities investigated in one species remain inadequately investigated in another?","iteration_id":null,"iteration_title":null,"iteration_status":null,"result_summary":null}]